Microsatellite instability in ovarian neoplasms
نویسندگان
چکیده
منابع مشابه
Frequent microsatellite instability in epithelial borderline ovarian tumors.
To further define the genetic events that could lead to the development of borderline ovarian tumors (BOTs), we analyzed 13 microsatellite markers on chromosomes 3p and q in 18 BOTs and compared the results to 31 serous invasive epithelia] ovarian cancers (IEOCs). Five of the 18 BOTs showed microsatellite instability (MSI) at one or more loci, compared to only 2 of the 31 IEOCs studied (P < 0.0...
متن کاملClinical Significance of Microsatellite Instability in Sporadic Epithelial Ovarian Tumors
PURPOSE We evaluated the expression of microsatellite instability (MSI) in sporadic ovarian tumors using 5 standard and 9 new MSI markers to determine the clinical significance of MSI in sporadic epithelial ovarian tumors. MATERIALS AND METHODS MSI was examined in 21 borderline and 25 malignant ovarian tumors. Polymerase chain reaction (PCR) was performed using the 5 markers recommended by th...
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DNA instability, reflected in altered patterns of short tandem repeat sequences (microsatellites) in dividing cells, has been described in hereditary non-polyposis colon cancer (HNPCC) and in other tumor types. Ovarian cancer (OC), although most often a sporadic cancer, can recur, with HNPCC, as part of the Lynch cancer family syndrome. In an investigation of microsatellite instability (MIN) in...
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Cystadenoma, which accounts for 40-50% of all ovarian new growths, is a tumour of adult life, and uncommon in patients under 20 years of age. We have seen two cases, a girl (E.G.) of 13 with a rightsided, thin-walled, unilocular cystadenoma measuring 17 x 13 x 10 cm., and a 12-year-old child (M.O.) with a small, left-sided, multilocular cystadenoma; neither of these two girls had menstruated.
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The genome of colorectal carcinomas displaying pronounced microsatellite instability codes for an extraordinarily high number of mutated proteins that elicit tumor-specific cellular immune responses. We have recently demonstrated that leukemic cells are also vulnerable to T cells specific for tumor-associated antigens produced in the context of microsatellite instability. This finding extends o...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1995
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1995.341